Xanax should not be taken with ketoconazole or itraconazole. Alcohol should be avoided by patients taking benzodiazepines. Xanax can lead to addiction (dependency), especially at high dosages over prolonged periods of time. Because of Xanax's addicting potential, dosages should never be increased by the patient. In patients addicted to Xanax, abrupt discontinuation of the medicine can lead to symptoms of withdrawal (insomnia, headaches, nausea, vomiting, light headedness, sweating , anxiety, and fatigue). Seizures can occur in more severe cases of withdrawal. Consequently, patients on alprazolam for extended periods of time should slowly taper the medication under a doctor's supervision rather than abruptly stopping the medication.

Xanax is habit forming. You can become physically and psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if Xanax is stopped suddenly after several weeks of continuous use. Seizures may be a side effect of sudden discontinuation of the medication. Your doctor may recommend a gradual reduction in dose.